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extend our understanding of the mechanism of action of metformin and provide further insights into the benefits of combining metformin with incretin-based drugs to combat diabetes
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Administration of -adrenergic receptor blockade reduces BAT 18F-FDG uptake (Soderlund et al., 2007) in patients with known or suspected cancer as well as in a patient with paraganglioma, a condition characterized by a massively increased metabolic BAT activity, induced by excess circulating catecholamines (Cheng et al., 2012)
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Additionally, variations in the methodologies utilized to evaluate retinopathyranging from clinical assessments to imaging techniquescan lead to inconsistencies in the outcomes reported
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